C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) C12N 9/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2301158
The present invention relates to drug screening assays useful in the discovery of pharmaceutically active compounds for use in the treatment of diseases involving abnormal lipid metabolism including diabetic neuropathy, by utilizing fatty acid desaturase enzymes and the genes which encode them as targets for intervention. The drug screening method serves to identify nucleotides, proteins, compounds and/or other pharmacological agents which effectively modulate the activity of desaturase enzymes or regulate the level of expression of the desaturase genes. Cell-based and cell lysate assays are used to detect components that interact with the desaturase enzymes either as enhancers or inhibitors of desaturation, and hence, modify fatty acid profiles. In addition, cell-based and cell lysate assays are used to identify functional and regulatory elements controlling expression of the desaturase genes as well as to screen for components that modulate the transcriptional activity of the desaturase genes.
Allen Stephen J.
de Antueno Roberto J.
Ponton Andre
Smith Heidi Lynn
Winther Michael D.
Allen Stephen J.
de Antueno Roberto J.
Ponton Andre
Ridout & Maybee Llp
Scotia Holdings Plc
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