Screening methods for transfusion related acute lung injury...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/705 (2006.01) C12N 15/12 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2735138

The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA- 3b nucleic acids in a sample of a biological tissue intended for transplantation

Linvention concerne la découverte selon laquelle HNA-3a et HNA-3b sont des antigènes dans une séquence de polypeptides qui présente une grande similarité avec la séquence dacides aminés CTL2. Cette invention concerne des procédés et des kits pour le criblage danticorps spécifiques à HNA-3a et HNA-3b, de polypeptides HNA-3a et HNA-3b, et dacides nucléiques HNA-3a et HNA-3b dans un échantillon dun tissu biologique prévu pour une transplantation.

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