C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 38/43 (2006.01) A61K 39/29 (2006.01) C07K 14/18 (2006.01) C12N 9/14 (2006.01) C12Q 1/34 (2006.01) C12Q 1/42 (2006.01) G01N 33/53 (2006.01) G01N 33/576 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2289453
Disclosed are screening methods to identify molecules which activate or inhibit the activity of an ATPase protein of the Flaviviridae family, particularly NS4B protein of Hepatitis C Virus (HCV). These inhibitors and activators of HCV NS4B protein potentially can be used as antiviral compounds and as therapeutic agents for the treatment of viruses linked to the Flaviviridae family, particularly HCV, flaviviruses such as yellow fever virus, Dengue virus types 1-4, and pestiviruses such as bovine viral diarrhea virus and classic swine fever, among others.
L'invention concerne des méthodes de criblage permettant d'identifier des molécules activant ou inhibant l'activité d'une protéine ATPase de la famille des Flaviviridae, en particulier la protéine NS4B du virus de l'hépatite C (VHC). Ces inhibiteurs et ces activateurs de la protéine NS4B du VHC peuvent être potentiellement utilisés comme composés antiviraux et comme agents thérapeutiques destinés au traitement de virus liés à la famille des Flaviviridae, en particulier le VHC, les flavivirus tels que le virus de la fièvre jaune, les virus de la dengue de type 1 à 4 et les pestivirus tels que le virus de la diarrhée virale des bovins et la peste porcine classique, entre autres.
Delvecchio Alfred
Zhong Weidong
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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