C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/635 (2006.01) A61K 38/29 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) C12N 15/16 (2006.01) C40B 30/04 (2006.01) G01N 33/566 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2694667
The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides.
La présente invention porte sur des procédés de criblage de GPCR fondés sur le fait que l'affinité d'un agoniste de récepteur pour un GPCR (tel que le récepteur de l'hormone parathyroïdienne) non lié à une protéine G est corrélée à la durée de l'efficacité de l'agoniste, indépendamment de ses propriétés pharmaco-cinétiques. L'invention porte également sur des polypeptides issus de PTH et de PTHrP.
Gardella Thomas J.
Ichikawa Fumihiko
Juppner Harald
Okazaki Makoto
Potts John T. Jr.
Borden Ladner Gervais Llp
Chugai Pharmaceutical Co. Ltd.
The General Hospital Corporation
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