C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01)
Patent
CA 2502544
The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [<I>PSI+</I>], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the ade1-14 allele of the <I>ADE1</I> gene and an inactivated <I>ERG6</I> gene, the screening methods, and a family of molecules with anti-prion activity isolated by the inventive screen. The invention is applicable to anti-prion agents for producing medicines in particular for treating neurodegenerative diseases involving protein aggregates.
La présente invention est relative à du criblage de molécules à activité anti- prion. Elle vise plus particulièrement des kits de criblage de molécules à activité anti-prion, caractérisés en ce qu'ils comportent en combinaison une levure de phénotype [PSI+], un antibiogramme et un agent de curage des prions à des doses sub-efficaces, ladite levure présentant l'allèle adel-14 du gène ADE1 ainsi qu'un gène ERG6 inactivé, les méthodes de criblage, et une famille de molécules à activité anti-prion mie en évidence à l'aide du crible selon l'invention. Application des agents anti-prion pour fabriquer des médicaments en particulier pour le traitement de maladies neurodégénératives impliquant des agrégats protéiques.
Bach Stephane
Blondel Marc
Cullin Christophe
Mettey Yvette
Talarek Nicolas
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Centre National de La Recherche Scientifique (c.n.r.s.)
Universite de Poitiers
Universite Victor Segalen - Bordeaux 2
LandOfFree
Screening molecules with anti-prion activity: kits, methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Screening molecules with anti-prion activity: kits, methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening molecules with anti-prion activity: kits, methods... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2064385