C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/37, 195/1.10
C12P 21/08 (2006.01) C07K 16/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/531 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2012088
SCREENING SYSTEM Abstract of the Disclosure A screening system for use in a method for the production of antibodies to an immunogen, wherein hybridoma culture supernatants are screened using cells infected with a virus recombinant encoding one or more epitopes of the immunogen, which infected cells are first subjected to one or more procedures conventional for the preparation of clinical samples to be arranged for the presence of said epitopes. The system disclosed is particularly advantageous as: 1) cells infected with the virus recombinant can provide a good supply of an antigen; 2) the antigen is expressed in a mammalian cell and it is therefore synthesized and processed in a form essentially identical to the antigen found in a natural infection; and 3) because the infected cells are subjected to one or more pre-treatments as applied to test sample tissues before their use in the hybridoma screening procedure, this ensures that the antibodies selected will recognize epitopes resistant to these pre-treatment and which may therefore be expected to be present on the test samples as prepared for analysis.
Bereskin & Parr
Lynxvale Limited
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