C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) C12N 15/10 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2350827
The invention relates to a method for producing a zinc finger nucleic acid binding protein comprising preparing a zinc finger protein according design rules, varying the protein at one or more positions, and selecting variants which bind to a target nucleic acid sequence by polysome display.
L'invention concerne un procédé de production d'une protéine de fixation d'acides nucléiques à motifs en doigt de zinc, consistant à préparer une protéine à motifs en doigt de zinc, selon des règles de construction, à modifier la protéine au niveau d'au moins une position, et à choisir des variants de cette protéine qui se lient à une séquence d'acides nucléiques cible, par expression de polysomes.
Choo Yen
Moore Michael
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Gendaq Limited
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