C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/72 (2006.01) C12N 5/06 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2501872
The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify CAR ligands, including compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.
L'invention concerne des souris possédant une activité de récepteur CAR réduite et des souris exprimant un récepteur CAR humain. Ces souris sont utiles dans des méthodes de criblage pour l'identification de ligands de CAR, dont des composés qui modulent l'activité du récepteur CAR, des composés susceptibles de présenter une toxicité médiée par CAR, et des analogues de ces composés présentant une toxicité potentielle moindre.
Chua Steven S.
Moore David D.
Wei Ping
Baylor College Of Medicine
Borden Ladner Gervais Llp
Chua Steven S.
Moore David D.
Wei Ping
LandOfFree
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