Scriptaid isosteres and their use in therapy

Details Scriptaid isosteres and their use in therapy Scriptaid isosteres and their use in therapy

C - Chemistry, Metallurgy

07

D

C07D 213/24 (2006.01) A61K 31/4402 (2006.01) A61K 31/444 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 213/74 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2750086

Compounds of the invention are of the formula (I); wherein: ... is a double bond and X is C; or ... is a single bond and X is N, CH or CQR1; and wherein: n is 1 to 10; R is H or QR1; each R' is independently selected from H and QR1; each Q is independently selected from a bond, CO, NH, S, SO, SO2 or O; each R1 is independently selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, substituted or unsubstituted aryl or heteroaryl, acyl, C1-C10 cycloalkyl, halogen, C1-C10 alkylaryl or C1-C10 heterocycloalkyl; L is a nitrogen-containing heteroaryl; and W is a zinc- chelating residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in therapy.

L'invention porte sur des composés représentés par la formule (I); dans laquelle : représente une double liaison et X représente C; ou représente une simple liaison et X représente N, CH ou CQR1 ; et dans laquelle : n vaut 1 à 10; R représente H ou QR1; chaque R' est indépendamment choisi parmi H et QR1; chaque Q est indépendamment choisi parmi une liaison, CO, NH, S, SO, SO2 ou O; chaque R1 est indépendamment choisi parmi alkyle en C1-C10, alcényle C2-C10, alcynyle en C2-C10, aryle ou hétéroaryle substitué ou non substitué, acyle, cycloalkyle en C1-C10, halogène, alkylaryle en C1-C10 ou hétérocycloalkyle en C1-C10; L représente un hétéroaryle contenant de l'azote; et W représente un résidu chélatant le zinc; ou un sel pharmaceutiquement acceptable correspondant. Les composés sont utiles en thérapie.

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