Scrotonergic .alpha.-oxoacetamide

Details Scrotonergic .alpha.-oxoacetamide Scrotonergic .alpha.-oxoacetamide

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/435 (2006.01) C07D 451/00 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2057181

.alpha.-OXOACETAMIDE DERIVATIVES ABSTRACT OF THE DISCLOSURE .alpha.-Oxoacetamides represented by Formula I Image wherein R1 is selected from Image (a) Image (b) Image (c) Image (d) in which: the dashed line denotes an optional bond; X and Y are independently selected from hydrogen, halo, cyano, hydroxy, lower alkoxy, benzyloxy, lower alkyl, nitro, amino, aminocarbonyl, (lower alkyl)amino, di(lower alkyl)amino, and (lower alkanoyl)amino; Z is -O-, -S- or -N(R4)-; and R4 and R5 are independently selected from hydrogen or lower alkyl or (lower cycloalkyl) lower alkyl or are together -(CH2)n- wherein n is an integer from 3 to 5; R2 is selected from Image (e) Image (f) Image (g) Image (h) in which: p is 0 or 1; q is 1, 2 or 3; and R6 is C1-7 alkyl; and R3 is selected from hydrogen or lower alkyl; their pharmaceutically acceptable salts, individual isomers and mixtures of isomers, processes for their preparation, compositions, and methods of use thereof.

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