C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 31/404 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2401016
Disclosed are compounds having a scytoneman skeleton, such as scytonemin, end methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.
L'invention porte sur des composés ayant un squelette scytoneman tel que la scytonémine et sur leurs procédés d'utilisation. L'invention porte également sur des procédés d'utilisation d'un composé ayant un squelette scytoneman pour inhiber, moduler, atténuer ou prévenir la progression d'un cycle cellulaire, la prolifération cellulaire, l'activité de la kinase ou pour induire l'apoptose. L'invention porte également sur des procédés de traitement, prévention ou inhibition de pathologies et troubles associés à la progression du cycle cellulaire, la prolifération cellulaire, l'activité de la kinase, l'hyperplasie tissulaire ou l'angiogenèse tels que le cancer ou autre maladie inflammatoire.
Gerwick William H.
Jacobs Robert S.
Marshall Lisa A.
Stevenson Christopher S.
Glaxosmithkline
Ridout & Maybee Llp
State Of Oregon
University Of California
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