C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A61K 39/02 (2006.01) A61K 39/085 (2006.01) A61K 39/38 (2006.01) C07H 21/04 (2006.01) C07K 2/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2526753
An isolated and/or purified Sdr surface protein from S. capitis and nucleic acids encoding them are provided which includes the SdrX protein which possesses collagen binding activites and the SdrZL protein which possesses SdrZ-like properties. The Sdr surface proteins from S. capitis can be used in pharmaceutical compositions to treat and prevent S. capitis infectionm and can also be used in vaccines and to raise antibodies which can treat or prevent such infections. Because the SdrX protein has been shown to have collagen binding abilities, antibodies to SdrX will have the ability to inhibit or prevent the ability ofS. capitis to bind to collagen.
L'invention concerne des protéines de surface Sdr isolées et/ou purifiées de S. capitis et des acides nucléiques qui les codent, comprenant la protéine SdrX qui traite les activités de liaison au collagène et la protéine SdrZL qui traite les propriétés semblables à SdrZ. Les protéines de surface Sdr de S. capitis peuvent être utilisées dans des compositions pharmaceutiques afin de traiter et de prévenir l'infection de S.capitis et peut aussi être utilisées dans des vaccins afin de déclencher des anticorps qui peuvent traiter ou prévenir ces infections. Etant donné que la protéine SdrX possède des capacités de liaison au collagène, les anticorps de SdrX peuvent inhiber ou prévenir la capacité de S.capitis de se lier au collagène.
Liu Yule
Patti Joseph
Vernachio John
Blake Cassels & Graydon Llp
Inhibitex Inc.
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