Seamless capsule containing water-soluble active substance

Details Seamless capsule containing water-soluble active substance Seamless capsule containing water-soluble active substance

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 31/335 (2006.01) A61K 47/02 (2006.01) A61K 47/04 (2006.01) A61K 47/06 (2006.01) A61K 47/14 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) A61K 47/44 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2563680

A seamless capsule which contains a water-soluble active ingredient and in which the water-soluble active ingredient is prevented from becoming instable; and a process for producing the capsule. The seamless capsule comprises: contents comprising a water-soluble active ingredient and an oily substance; a film with which the contents are covered; and an interlayer which is disposed between the contents and the film and comprises an oily substance in which the water-soluble active ingredient is insoluble or immiscible and which is insoluble in or immiscible with water, has a melting point in the range of 10- 65~C, and does not dissolve in or mix with the contents at any temperature not higher than the melting point during the capsule production. The process, which is for producing a seamless capsule containing a water-soluble active ingredient, employs an apparatus for seamless-capsule production which has a multiannular nozzle having three or more annular orifices with diameters increasing in order.

Il est prévu une capsule sans couture contenant un ingrédient actif soluble dans l'eau et dans laquelle l~ingrédient actif soluble dans l'eau ne peut pas devenir instable ; et un procédé de fabrication de la capsule. La capsule sans couture comprend : des éléments comprenant un ingrédient actif soluble dans l'eau et une substance huileuse ; un film recouvrant les éléments ; et une intercouche qui est disposée entre les éléments et le film et comprend une substance huileuse dans laquelle l~ingrédient actif soluble dans l'eau est insoluble ou immiscible et qui est insoluble ou immiscible avec l~eau, possède un point de fusion dans une fourchette de 10 à 65·C, et ne se dissout pas ou ne se mélange pas avec les éléments à n~importe quelle température ne dépassant pas le point de fusion pendant la fabrication des capsules. Le procédé de fabrication d~une capsule sans couture contenant un ingrédient actif soluble dans l'eau fait appel à un appareil pour la production de capsules sans couture, ayant une buse multiannulaire possédant trois orifices ou davantage avec des diamètres croissants.

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