C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/30 (2006.01) A61K 31/40 (2006.01) C07D 209/10 (2006.01) C07D 209/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2272952
The present invention relates to novel amino analogues of the general class of cyclopropylindoles and their seco precursors, and is particularly concerned with the use of these compounds as prodrugs for antibody-directed enzyme- prodrug therapy (ADEPT) and gene-directed enzyme-prodrug therapy (GDEPT) for cancer.
La présente invention concerne de nouveaux analogues amino de la classe générale des cyclopropylindoles et des précurseurs seco de ceux-ci, et elle concerne notamment l'utilisation de ces composés en tant que promédicaments destinés à une thérapie du cancer par administration d'un de ces promédicaments et d'un conjugué anticorps-enzyme (ADEPT), ou par administration d'un de ces promédicaments et d'un conjugué anticorps-gène (GDEPT).
Atwell Graham John
Denny William Alexander
Milbank Jared
Tercel Moana
Auckland Uniservices Limited
Cancer Research Campaign Technology Limited
Kirby Eades Gale Baker
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