C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/255, 167/283
C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07J 7/00 (2006.01)
Patent
CA 1329589
Abstract A pharmaceutical composition for use in inducing cell differentiation of leukemia cells in a patient. The composition employs seco-sterol compounds which are similar in structure to known vitamin D compounds since they contain the identical ring structure or nucleus, but are different in that they contain a shortened side chain comprising a hydrogen, methyl, ethyl or propyl attached at the carbon 20 position. Functionally. the seco- sterols do not express the classic vitamin D calcemic activities in vivo. The seco-sterols thus may be administered to cause differentiation of malignant cells to normal cells without producing simultaneously unphysiologically high and deleterious blood calcium levels.
603774
de Luca Hector F.
Lau Wan Fang
Schnoes Heinrich K.
de Luca Hector F.
Lau Wan Fang
Osler Hoskin & Harcourt Llp
Schnoes Heinrich K.
Wisconsin Alumni Research Foundation
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