Second messenger cell signaling inhibitors

Details Second messenger cell signaling inhibitors Second messenger cell signaling inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/00 (2006.01) A61K 31/45 (2006.01) A61K 31/47 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) A61K 38/05 (2006.01) C07C 215/08 (2006.01) C07C 215/56 (2006.01) C07C 217/62 (2006.01) C07C 229/22 (2006.01) C07C 233/36 (2006.01) C07C 233/78 (2006.01) C07C 233/91 (2006.01) C07C 237/06 (2006.01) C07D 207/404 (2006.01) C07D 209/48 (2006.01) C07D 211/76 (2006.01) C07D 211/88 (2006.01) C07D 217/24 (2006.01) C07D 239/54 (2006.01) C07D 239/88 (2006.01) C07D 239/90

Patent

CA 2159640

The invention provides a group of compounds that are effective agents to inhibit specific cellular signaling events often induced by inflammatory stimuli, to act as anti-inflammatory or immunosuppressive agents, to act as cytotoxic agents for treatment of cancers, or to be directly or indirectly antimicrobial to yeast or fungal infections. More specifically, the inventive compounds have at least one amino alcohol (or derivative thereof) functional group on a side chain attached to a core moiety. The inventive compounds are useful antagonists to control intracellular levels of specific sn-2 unsaturated phosphatidic acids and corresponding phosphatidic acid-derived diacylglycerols, intracellular cell signaling messengers which occur in response to pro- inflammatory and selectively proliferative stimuli.

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