Secondary amines

Details Secondary amines Secondary amines

C - Chemistry, Metallurgy

07

C

260/361.1, 260/4

C07C 43/313 (2006.01) C07C 43/225 (2006.01) C07C 43/303 (2006.01) C07C 229/38 (2006.01) C07D 307/81 (2006.01)

Patent

CA 1253870

ABSTRACT A compound of formula (I): Image (I) or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula Image wherein R1 is hydrogen or fluorine, R2 is hydrogen, C1-6 alkyl, halogen or trifluoromethyl; or W is a phenoxymethyl or benzofuran-2-yl group; R3 is C1-12 alkyl or phenyl C1-6 alkyl; A is hydrogen or methyl, X is carboxy, -Z-CO2H, -Z-OH, T-Z-CO2H, -Z-NR4R5, -T-Y-OM, -T-Y-NR4R5, or -T-R6, in the para- or meta-position with respect to the -(CH2)n group, wherein R4 and R5 are each hydrogen or C1-6 alkyl, R6 is C1-6 alkyl, T is 0, S, -NH or -N-R7, in which R7 is C1-6 alkyl Z is C1-10 straight or branched alkylene optionally containing a carbon-carbon double bond; Y is C2-10 straight or branched alkylene, provided that the hetero atoms in -T-Y-OM and -T-Y-NR4R5 are separated by at least two carbon atoms, M is hydrogen, C1-6 alkyl or phenyl, and n is 1 or 2, is useful for obesity or hyperglycaemia.

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