C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/16 (2006.01) A61K 39/04 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) C12N 15/52 (2006.01) C12N 15/55 (2006.01) C12N 15/67 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2501941
The invention relates to an isolated DNA construct, comprising a mycobacterium secreted acid phosphatase promoter or promoter fragment which is inducible by low pH. This invention further relates to diagnostic methods and vaccines for treatment or prophylaxis of pathogenic mycobacterial disease or infection. This invention also provides for methods of screening for compounds capable of modulating the activity, production or secretion of a mycobacterium secreted acid phosphatase.
La présente invention concerne un ADN hybride isolé comprenant un promoteur ou un fragment de promoteur de phosphatase acide sécrétée mycobactérienne qui peut être induit par un faible pH. L'invention concerne en outre des procédés de diagnostic et des vaccins destinés au traitement ou à la prophylaxie de maladies ou infections causées par des mycobactéries pathogènes. L'invention se rapporte également à des procédés de criblage de composés capables de moduler l'activité, la production ou la sécrétion d'une phosphatase acide sécrétée mycobactérienne.
Alexander David
Liu Jun
Saleh Mazen T.
Alexander David
Gowling Lafleur Henderson Llp
Liu Jun
Saleh Mazen T.
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