Secreted human fas antigen

Details Secreted human fas antigen Secreted human fas antigen

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211038

Disclosed is a natural, soluble form of the Fas antigen polypeptide that is secreted by human cells and is the result of alternative mRNA processing in the cell. This variant of Fas is shown to be present at higher levels in patients with SLE and AILD. Also disclosed are nucleic acids encoding this unique form of the Fas antigen and methods for making and using the protein and nucleic acids, including various diagnostic embodiments such as ELISAs.

L'invention porte sur une forme naturelle solide du polypeptide antigène du Fas sécrété par les cellules humaines et résultant de traitements différents de l'ARNm dans la cellule. Il est démontré que cette variante du Fas est présente en quantités plus élevées chez les malades atteints du SLE et de l'AILD. L'invention porte également sur des acides nucléiques codant pour cette forme unique du Fas et sur des procédés de préparation et d'utilisation de la protéine et des acides nucléiques, et porte aussi sur différentes méthodes de diagnostics tels que l'ELISA.

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