C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/24 (2006.01) A61K 38/47 (2006.01) C12N 15/56 (2006.01) C12Q 1/34 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2512629
The invention provides novel human secreted polypeptides comprising an amino acid sequence of SEQ ID NOS 3-4. The polypeptides of the invention circulate at a reduced level in the plasma of patients with cardiovascular disorders. The invention also provides compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides. Also provided are methods for making such compositions, and methods of using the compositions of the invention for diagnosis, prognosis, and treatment of cardiovascular disorders.
L'invention concerne des nouveaux polypeptides humains sécrétés comprenant une séquence d'acides aminés SEQ ID NOS 3-4. Les polypeptides de l'invention circulent à un niveau réduit dans le plasma de patients présentant des troubles cardiovasculaires. L'invention concerne également des compositions comprenant lesdits polypeptides, des polynucléotides les codant, et des anticorps spécifiques pour ces polypeptides. L'invention concerne en outre des procédés de production desdites compositions, et des procédés d'utilisation de celles-ci destinés au diagnostic, au pronostic, et au traitement de troubles cardiovasculaires.
Bougueleret Lydie
Cusin Isabelle
Fetherstonhaugh & Co.
Genova Ltd.
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