Secretion of insulin-like growth factor-i in e. coli

C - Chemistry – Metallurgy – 12 – N

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195/1.235, 195/1

C12N 15/16 (2006.01) C07K 14/24 (2006.01) C07K 14/65 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1314507

SECRETION OF INSULIN-LIKE GROWTH FACTOR I IN F. COLI Abstract A method for bacterially producing IGF-I is disclosed in which Gram-negative bacteria are caused to express a gene consisting of a lamB or ompF signal sequence operatively joined to a DNA sequence encoding IGF-I and producing IGF-I which is secreted into the periplasmic space of the bacteria.

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