C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2480159
The invention provides methods for using the Twin Argentine Translocation pathway in bacteria to produce heterologous polypeptides that have multiple disulfide bonds. Methods of screening polypeptide libraries produced by secretion through the TAT pathway are also provided. The invention provides improved methods for production of heterologous polypeptides having at least one disulfide bond.
Cette invention a trait à des méthodes d'utilisation de la voie de la translocation des arginines couplées chez des bactéries pour produire des polypeptides hétérologues ayant plusieurs liaisons disulfure. Elle concerne également des méthodes de criblage de bibliothèques polypeptidiques produites par sécrétion dans la voie de la TAT. Elle porte, de surcroît, sur des procédés améliorés de production de polypeptides hétérologues ayant au moins une liaison disulfure.
Delisa Matthew
Georgiou George
Masip Lluis
Borden Ladner Gervais Llp
Research Development Foundation
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