Secretory phospholipase a2 (spla2) inhibitor and niacin drug...

A - Human Necessities – 61 – K

Patent

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A61K 31/405 (2006.01) A61K 31/366 (2006.01) A61K 31/403 (2006.01) A61K 31/455 (2006.01) A61K 31/4965 (2006.01) A61K 31/522 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2749534

Niacin drugs are frequently utilized as a therapeutic to treat CVD, increase HDL levels, and/or decrease TG levels. As disclosed herein, it has been found that administration of one or more sPLA2 inhibitors in combination with one or more niacin drugs unexpectedly results in a synergistic increase in HDL levels and a synergistic decrease in TG levels. Therefore, compositions, methods, and kits are provided for treating CVD, increasing HDL levels, decreasing TG levels, and improving HDL/LDL ratios.

Les médicaments à base de niacine sont fréquemment utilisés en tant qu'agents thérapeutiques pour traiter les maladies cardiovasculaires, augmenter les taux de HDL et/ou réduire les taux de triglycérides. Selon la présente invention, il a été trouvé que l'administration d'un ou de plusieurs inhibiteurs de sPLA2 en combinaison avec un ou plusieurs médicaments à base de niacine a entraîné de façon inattendue une augmentation synergique des taux de HDL et une réduction synergique des taux de triglycérides. Par conséquent, l'invention concerne des compositions, des méthodes et des trousses afin de traiter les maladies cardiovasculaires, d'augmenter les taux de HDL, de réduire les taux de triglycérides et d'améliorer les rapports HDL/LDL.

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