C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01) A61K 31/58 (2006.01)
Patent
CA 2044905
8364/SCM101 18138 TILE OF THE INVENTION SELECTED 17.beta.-POLYAROYL-4-AZA-5a-ANDROST-1- EN-3-ONES AS STEROIDAL REDUCTASE INHIBITORS ABSTRACT OF THE INVENTION SELECTED 17.beta.-POLYAROYL-4-AZA-5a-ANDROST-1- EN-3-ONES AS STEROIDAL REDUCTASE INHIBITORS OF THE FORMULA: Image I 8364/SCM101 18138 wherein R is selected from hydrogen, methyl and ethyl R2 is a polycyclic aromatic radical which can be substituted with one or more of: -OH, protected -OH, -OC1-C4 alkyl, C1-C4 alkyl, or nitro, wherein the dotted line represents a double bond which can be present, and pharmaceutically acceptable salts or esters thereof, and a pharmaceutical formulation. The above compounds are active as steroidal reductase inhibitors and thus are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.
Rasmusson Gary H.
Salzmann Thomas N.
Steinberg Nathan G.
Merck & Co. Inc.
Rasmusson Gary H.
Salzmann Thomas N.
Steinberg Nathan G.
Swabey Ogilvy Renault
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