Selected cgrp antagonists method for production and use...

Details Selected cgrp antagonists method for production and use... Selected cgrp antagonists method for production and use...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/551 (2006.01)

Patent

CA 2626009

The invention relates to the CGRP antagonists of general formula (I), where R1, R2, R3 and R4 are as defined in claim 1, the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof and the hydrates of the salts, in particularly the physiologically-acceptable salts with inorganic or organic acids or bases and any compound of general formula (I), in which one or more hydrogen atoms are exchanged for deuterium, medicaments comprising said compounds the use and methods for production thereof.

L'invention se rapporte à des agonistes du CGRP de formule générale (I) dans laquelle R1, R2, R3 et R4 sont tels que définis dans la première revendication. Cette invention concerne également leurs tautomères, isomères, diastéréo-isomères, énantiomères, hydrates, mélanges, et leurs sels, ainsi que les hydrates de leurs sels, en particulier leurs sels physiologiquement compatibles qui comportent des acides ou des bases inorganiques ou organiques. L'invention concerne également les composés de formule (I) dont un ou plusieurs atome(s) d'hydrogène a/ont été remplacé(s) par du deutérium. La présente invention se rapporte en outre à des médicaments contenant lesdits composés, à l'utilisation de ces composés, et à leur procédé de production.

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