C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61P 25/06 (2006.01)
Patent
CA 2618834
The invention relates to the CGRP antagonists of general formula (I) in which R1, R2, R3 and R4 are defined as in claim 1, to their tautomers, isomers, diastereoisomers and enantiomers, hydrates, mixtures and their salts as well as the hydrates of the salts, particularly their physiologically compatible salts with inorganic or organic acids or bases, as well as to the compounds of general formula (I) in which one or more hydrogen atoms are exchanged for deuterium, to medicaments containing these compounds, the use thereof and to methods for the production thereof.
L'invention concerne les antagonistes CGRP de la formule générale I où R1, R2, R3 et R4 ont la définition donnée dans la revendication 1, leurs tautomères, leurs isomères, leurs diastèreomères, leurs énantiomères, leurs hydrates, leurs mélanges et leurs sels ainsi que les hydrates des sels, notamment leurs sels physiologiquement tolérables contenant des acides ou bases inorganiques ou organiques, ainsi que les composés de la formule générale I où au moins un atome d'hydrogène est échangé par deuterium, les médicaments contenant ces composés, leur utilisation et leur procédé de production.
Arndt Kirsten
Doods Henri
Lustenberger Philipp
Mueller Stephan Georg
Rudolf Klaus
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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