Selected cgrp antagonists, processes for preparing them and...

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2503462

The invention relates to CGRP antagonists of general formula (I), in which A, X, Y, Z and R1 to R 3 are as defined in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures, salts, hydrates of the salts, in particular the physiologically-acceptable salts thereof with inorganic or organic acids, medicaments containing said compounds and the use and methods for production thereof.

La présente invention concerne des antagonistes du peptide lié au gène de la calcitonine (CGRP) de formule générale (I), dans laquelle A, X, Y, Z et R?1¿ à R?3¿ sont tels que définis dans la revendication 1, leurs tautomères, leurs diastéréoisomères, leurs énantiomères, leurs hydrates, leurs mélanges, leurs sels et les hydrates de ces sels, en particulier leurs sels physiologiquement acceptables avec des acides organiques ou inorganiques, des médicaments contenant ces composés, leur utilisation ainsi que des procédés de production desdits composés.

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