Selected rna motifs to include cell death and/or apoptosis

Details Selected rna motifs to include cell death and/or apoptosis Selected rna motifs to include cell death and/or apoptosis

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 43/04 (2006.01) A61K 31/07 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2520181

The present application is directed to the use of dsRNA and/or ssRNA for the purpose of inducing apoptosis or cell death in proliferating cells. Specifically, low molecular weight and high molecular weight dsRNA and ssRNA are shown to induce apoptosis and/or cell death in proliferating cells, to arrest proliferation of transformed cells or tumor cells and to cause rapid induction of the cytokine TNF-alpha and/or also induce production of IL-12 which directs a Th-1 response.

Cette invention se rapporte à l'utilisation d'ARNds et/ou d'ARNss en vue d'induire l'apoptose ou la mort cellulaire dans des cellules en cours de prolifération. Cette invention propose plus spécifiquement des ARNds et des ARNss de poids moléculaire faible et de poids moléculaire élevé destinés à induire l'apoptose et/ou la mort cellulaire dans des cellules en cours de prolifération, à stopper la prolifération de cellules transformées ou de cellules tumorales et à entraîner la production rapide du facteur de nécrose tumorale alpha par la cytokine et/ou à induire également la production d'interleukine 12 qui dirige la réponse des cellules Th-1.

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