Selectin binding glycopeptides

Details Selectin binding glycopeptides Selectin binding glycopeptides

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 31/70 (2006.01) A61K 38/14 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) C07H 7/02 (2006.01) C07H 13/04 (2006.01) C07H 15/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2168454

Glyco-amino acids or glycopeptides that have three-dimensionally stable configuration for the presentation of functional groups, fucose, or an analogue or derivative thereof, covalently linked to an amino acid or peptide with a free carboxylic acid group, that facilitate binding between those groups and receptors on selectins, represented by general structural formula (I) as shown in claim 1. The glycopeptides of structural formula (I) can be administered to a subject to treat inflammation.

L'invention concerne des acides glyco-amino ou glycopeptides qui ont une configuration stable, tridimensionnelle, s'adaptant à la présentation de groupes fonctionnels, du fucose ou un analogue ou un dérivé de celui-ci, liés de manière covalente à un acide aminé ou peptide par un groupe acide carboxilique libre, et qui facilitent la liaison entre ces groupes et des récepteurs sur les sélectines. Ces glycopeptides sont représentés par la formule structurale générale (I) illustrée dans la revendication 1. Les glycopeptides de la formule structurale (I) peuvent être administrés à un sujet pour traiter une inflammation.

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