Selecting genes encoding catalytic antibodies

Details Selecting genes encoding catalytic antibodies Selecting genes encoding catalytic antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C12N 9/00 (2006.01) C12N 15/52 (2006.01) C12N 15/64 (2006.01)

Patent

CA 2159724

The present invention describes methods of screening for or selecting a catalytic antibody effective to cleave a target peptide. In particular, in the selection method of the present invention a phage gene is selected that encodes a gene product necessary for the production of a phage. The phage, carrying the modified gene is introduced into a host. Also, a library of rearranged immunoglobulin genes in a cloning vector is introduced into host cells. The host cells are grown under conditions in which the immunoglobulin genes are expressed in the host cells. The presence of antibodies capable of cleaving the target peptide is identified on the basis of production of phage.

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