Selection by compartmentalised screening

Details Selection by compartmentalised screening Selection by compartmentalised screening

C - Chemistry, Metallurgy

40

B

C40B 30/00 (2006.01) C40B 30/04 (2006.01) C40B 30/08 (2006.01) G01N 15/10 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2520548

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

Il s'agit d'un procédé visant à identifier des composés se liant à un composant cible d'un système biochimique ou modulant l'activité de la cible. Pour ce procédé: a) on compartimente les composés en microcapsules les associant à la cible, de façon qu'un seul sous-ensemble du répertoire soit représenté en plusieurs exemplaires dans l'une ou l'autre des microcapsules, puis: b) on identifie le composé qui se lie à la cible ou qui en module l'activité. L'invention permet ainsi un criblage de vastes répertoires de molécules pouvant servir de fils conducteurs à la mise au point de médicaments.

Affiliated with

Also associated with

Rating

Selection by compartmentalised screening does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Selection by compartmentalised screening, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selection by compartmentalised screening will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1876233