Selection of cells expressing heteromeric polypeptides

Details Selection of cells expressing heteromeric polypeptides Selection of cells expressing heteromeric polypeptides

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2458811

The invention utilizes selectable markers that can exist as two or more subunits that when expressed together will interact, thereby providing a selectable activity. The individual subunits do not have significant selectable activity alone, but do provide selectable activity when co-expressed with their counterpart subunit. The optimal activity of the subunits can depend upon their interaction, and as such can be facilitated by interaction domains. Such interaction domains can be endogenous to the subunit or it can be heterologous to the subunit.

L'invention concerne le domaine de l'expression par recombinaison de polypeptides dans la cultures de cellules animales, et concerne notamment la sélection améliorée, dans les cellules, de vecteurs modifiés par recombinaison et destinés à exprimer des polypeptides.

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