Selection of markers

Details Selection of markers Selection of markers

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61B 5/00 (2006.01) G01N 33/50 (2006.01) G06F 9/00 (2006.01) G06F 17/00 (2006.01) G06F 17/18 (2006.01) G01N 33/53 (2006.01) G01N 37/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2422309

Methods of selecting a portfolio of markers for use in a diagnostic applications include defining diagnostic parameters, establishing a relationship among the parameters so that they are optimized, and selecting an optimal group of markers for the diagnostic application. The diagnostic parameters can include a measure of the relative degree of expression of a gene, a measure of the variation in the measurement of the degree of expression of the gene, and the relationship between the diagnostic and discriminating parameters can be a mean variance relationship. Machines programmed to conduct the method and articles that comprise instructions for their operation are further aspects of the invention.

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