C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) C12N 7/01 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2328422
The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.
La présente invention concerne une méthode de sélection d'un virus, cette méthode consistant: a) à prendre un virus codant pour et présentant un polypeptide de fusion, lequel comprend un polypeptide hétérologue inséré dans la séquence d'un polypeptide à protéine de coque virale, ledit virus renfermant un site clivable situé à l'intérieur d'un polypeptide présenté; b) à exposer ce virus à un agent de clivage; et c) à propager ce virus comprenant une protéine de fusion intacte.
Jestin Jean-Luc
Kristensen Peter
Riechmann Lutz
Winter Gregory Paul
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Diversys Limited
Domantis Limited
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