Selective 5-ht6 receptor ligands

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/16 (2006.01) A61K 31/403 (2006.01) A61K 31/4045 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01) C07D 209/86 (2006.01)

Patent

CA 2353962

Compounds which have enhanced affinity and selectivity for 5-HT6 receptors have been identified. These compounds can be used therapeutically in the treatment of mental disorders via administration in a pharmacologically acceptable delivery route to a patient in need thereof, or can be used to identify antagonists of 5-HT6 receptors by well known screening methodologies which could themselves be used in the treatment of mental disorders.

L'invention concerne des composés qui présentent une affinité et une sélectivité améliorées pour les récepteurs de 5-HT6. Ces composés peuvent être utilisés pour traiter les troubles mentaux en étant administrés, par une voie pharmacologiquement acceptable, à des patients. En outre, ces composés peuvent être utilisés pour identifier les antagonistes des récepteurs de 5-HT6 à l'aide de techniques de dosage bien connues. Ces antagonistes peuvent eux-mêmes être utilisés dans le traitement des troubles mentaux.

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