Selective adenosine receptor agents

Details Selective adenosine receptor agents Selective adenosine receptor agents

C - Chemistry, Metallurgy

07

D

167/202, 167/220

C07D 473/00 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01) C07H 19/04 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2013380

Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo. Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.

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