Selective agonist of toll-like receptor 3

Details Selective agonist of toll-like receptor 3 Selective agonist of toll-like receptor 3

A - Human Necessities

61

K

A61K 31/7105 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2715293

A mismatched double-stranded ribonucleic acid, which is an agonist for Toll- like receptor 3 (TLR3), is used in vit-ro or in vivo as an antimicrobial agent, antiproliferative agent, and/or immunostimulant. Poly(1:C11-14U) is a more selective agonist of TLR3 as compared to poly(1:C) even though the both double-stranded RNA are structurally analogous.

L'invention concerne un acide ribonucléique double brin désapparié, antagoniste du récepteur 3 de type Toll (TLR3), utilisé in vitro ou in vivo comme agent antimicrobien, agent antiprolifératif et/ou immunostimulant. Poly(l:C11-14U) est un agoniste plus sélectif deTLR3 par rapport à poly(l:C) bien que les deux ARN double brin soient structurellement analogues.

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