C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/46 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2625436
The present invention is related to new peptide antagonists of .alpha.v.beta.3 receptor, designed on the basis of the crystal structure of integrin .alpha.v.beta.3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the .alpha.v.beta.3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for .alpha.v.beta.3- targeted therapy and imaging.
La présente invention concerne de nouveaux antagonistes peptidiques du récepteur .alpha.v.beta.3, conçus sur la base de la structure cristalline de l'intégrine .alpha.v.beta.3 en complexe avec c(RGDf[NMe]V) et la structure NMR de l'échistatine. Ces peptides sont des antagonistes puissants et sélectifs du récepteur .alpha.v.beta.3 et peuvent être utilisés en tant que nouveaux médicaments anticancéreux et/ou en tant que nouvelle classe de traceurs de diagnostic non invasifs appropriés pour l'imagerie et la thérapie reposant sur .alpha.v.beta.3.
Del Gatto Annarita
Pedone Carlo
Saviano Michele
Zaccaro Laura
Advanced Accelerator Applications
Del Gatto Annarita
Gowling Lafleur Henderson Llp
Pedone Carlo
Saviano Michele
LandOfFree
Selective alfavbeta3 receptor peptide antagonist for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Selective alfavbeta3 receptor peptide antagonist for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective alfavbeta3 receptor peptide antagonist for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1865970