Selective alteration of antibody immunogenicity

Details Selective alteration of antibody immunogenicity Selective alteration of antibody immunogenicity

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2131621

2131621 9318792 PCTABS00025 The present invention relates to a simple process for the modification of, e.g., anti-TAA antibodies, which alters their immunogenicity so that their ability to induce an anti-isotypic response is selectively diminished, while they remain able to elecit an anti-idiotypic response. The latter is of potential immunotherapeutic value, i.e., by activation of the idiotype-anti-idiotype network. This modification takes the form of a controlled and partial reduction of the antibody; effector regions are retained. The invention should permit repeat injections (for diagnosis and therapy) and reduce HAMA interference in serodiagnostic assays.

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