Selective amylin antagonist peptides and uses therefor

Details Selective amylin antagonist peptides and uses therefor Selective amylin antagonist peptides and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2167301

Peptides having the structure: X-R1ThrGlnR2LeuAlaAsnR3LeuValArgLeuArgLeuGlnThrTyrProArgThrAsnValGlyR4AsnThrTyr-NH2 that inhibit amylin acdvity and that exhibit selectivity for amylin receptors reladve to calcitonin and CGRP receptors are provided. These peptides may be used in the treatment of conditions where it is of benefit to reduce amylin activity, including the treatment of Type 2 diabetes mellitus, impaired glucose tolerance, obesity, insulin resistance and hypertension.

Les peptides de la structure X-R1ThrGlnR2LeuAlaAsnR3LeuValArgLeuGlnThrTyrProArgThrAsnValGlyR4AsnThrTyr-NH2 de la présente invention ont une activité inhibitrice de l'amyline et exercent une action sélective sur les récepteurs de l'amyline par rapport aux récepteurs de la calcitonine et de CGRP (peptide lié au gène de la calcitonine). Ces peptides sont utilisables dans le traitement d'états où il est intéressant de réduire l'activité de l'amyline, y compris le diabète sucré de type 2, l'intolérance au glucose, l'obésité, la résistance à l'insuline et l'hypertension.

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