C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/22 (2006.01) A61K 31/00 (2006.01) A61K 31/407 (2006.01) A61K 31/56 (2006.01) A61K 31/655 (2006.01) A61K 31/675 (2006.01) C07D 471/18 (2006.01) C07D 487/08 (2006.01) C07D 487/18 (2006.01) C07D 491/16 (2006.01) C07D 491/18 (2006.01) C07D 491/22 (2006.01) C07D 495/18 (2006.01) C07D 498/16 (2006.01) C07D 498/18 (2006.01) C07D 519/00 (2006.01) G01N 33/574 (2006.01) G06F 17/50 (2006.01)
Patent
CA 2413417
Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and using SARMs are provided.
L'invention concerne des modulateurs sélectifs des récepteurs androgéniques (SARM) présentant une activité antagoniste vis-à-vis des tumeurs hormonodépendantes tout en ne présentant aucune activité ou activité agoniste vis-à-vis des tissus non tumoraux contenant le récepteur androgène. L'invention concerne également des méthodes d'identification, d'élaboration et d'utilisation de ces modulateurs sélectifs des récepteurs androgéniques (SARM).
Attar Ricardo M.
Gottardis Marco M.
Krystek Stanley R. Jr.
Sack John S.
Salvati Mark E.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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