Selective antagonists of a2a adenosine receptors

Details Selective antagonists of a2a adenosine receptors Selective antagonists of a2a adenosine receptors

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/52 (2006.01) A61P 25/16 (2006.01)

Patent

CA 2658404

The present invention provides compounds of formulae (Ia) and (Ib): wherein R1-5, Q, X, Y, Z, p, q, and r are as defined herein. The compounds are potent and selective antagonists of A2A adenosine receptors (ARs). The invention further includes pharmaceutical compositions containing these compounds and methods of using the same.

L'invention concerne des composés répondant aux formules (Ia) et (Ib), dans lesquelles R1-5, Q, X, Y, Z, p, q, et r sont tels que définis dans la description. Les composés précités sont de puissants antagonistes sélectifs des récepteurs de l'adénosine A2A. L'invention se rapporte en outre à des compositions pharmaceutiques contenant lesdits composés et à des procédés d'utilisation de ces dernières.

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