Selective antitumor agent

A - Human Necessities – 61 – K

Patent

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167/129, 167/139

A61K 39/395 (2006.01) A61K 35/78 (1985.01) A61K 37/00 (1985.01)

Patent

CA 1202897

ABSTRACT OF THE DISCLOSURE This invention relates to a selective antitumor agent consisting of a special carrier portion and a voluntary antitumor ingredient. The carrier portion is a monoclonal antibody (MoAb) which is produced by a hybri- doma formed by cell fusion of two kinds of animal cells, one of which is an animal cell sensitized by human tumor cell such as spleen cell of BALB/c mouse and another of which is another animal cell such as mouse myeloma cell. The antibody is isolated from the hybridoma and chemical- ly bound with the voluntary antitumor ingredient such as an alkylating agent, an antimetabolic agent, a cytotoxic antibiotic protein or polypeptide, toxin, or alkaloid. The resultant medicine-MoAb conjugate selectively binds with specific tumor cells or tissue having corresponding antigens and the medicine selectively attacks said cells or tissue as its target.

418956

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