Selective binding of pathological forms of prion proteins...

Details Selective binding of pathological forms of prion proteins... Selective binding of pathological forms of prion proteins...

G - Physics

01

N

G01N 33/68 (2006.01) C08B 37/02 (2006.01)

Patent

CA 2477569

Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.

Selon l'invention, des formes agrégeantes infectieuses de protéines, notamment PrP, amyloïde, et tau sont liées sélectivement en présence de la protéine sous forme normale au moyen d'un agent liant polyionique tel que le dextran sulfate ou le pentosane sulfate (anionique), ou de composés polyamine tels que le pDADMAC (cationique), dans des conditions de liaison sélective incluant l'utilisation de n-lauroylsarcosine à pH légèrement alcalin. Les formes pathologiques de ces protéines peuvent alors être dosées.

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