Selective cell inactivation in blood

Details Selective cell inactivation in blood Selective cell inactivation in blood

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 31/40 (2006.01) A61K 31/409 (2006.01) A61K 35/14 (2006.01) A61K 41/00 (2006.01) A61M 1/36 (2006.01) A61N 5/06 (2006.01)

Patent

CA 2136447

Treatment with a set of porphyrin compounds using a photodynamic therapy approach is able selectively to lower elevated levels of activated leukocytes in a leukocyte population. By using compounds with absorption maxima of about 670 nm or higher, irradiation wavelengths can be selected to permit treatment of complex tissues, such as whole blood. This is particularly helpful in subjects containing such elevated levels of T-cell subsets, such as HIV- infected subjects.

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