Selective cell therapy for the treatment of renal failure

Details Selective cell therapy for the treatment of renal failure Selective cell therapy for the treatment of renal failure

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 35/23 (2006.01) A61K 38/18 (2006.01) A61P 7/06 (2006.01) C07K 14/505 (2006.01)

Patent

CA 2688265

Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro. The kidney cells may include peritubular interstitial cells of the kidney, and preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells produce EPO in vivo.

L'invention propose des populations isolées de cellules rénales récoltées parmi des cellules différenciées de rein, les cellules ayant été expansées in vitro. Les cellules rénales peuvent inclure des cellules interstitielles péritubulaires du rein, et de préférence produire de l'érythropoïétine (EPO). Les cellules rénales peuvent aussi être sélectionnées sur la base de la production d'EPO. Des procédés de production d'une population isolée de cellules produisant de l'EPO sont également proposés, et des procédés de traitement d'une maladie rénale résultant en une production diminuée d'EPO chez un patient qui en a besoin sont proposés, comprenant l'administration de la population au patient, les cellules produisant de l'EPO in vivo.

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