Selective chemokine modulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/24 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 37/04 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2663259

The present invention teaches the use of a metal or an oxide of a metal having a capability of reducing the amount of the chemokine IP-IO in a sample and/or reducing the production of IP-IO in cells. The metal is a metal of group 4 or 5 in the period table of the elements and preferably titanium. These metals and metal oxides can selectively bind IP-IO to its surface to thereby scavenge IP-IO from the surrounding medium. In addition, a metal-cell contact induces a reduction in the production of IP-IO from IP-IO producing cells. The metals and metal oxides of the present invention can therefore be used for treating and/ or preventing medical conditions characterized by adverse IP-IO expression, such as inflammatory reactions.

La présente invention concerne l'utilisation d'un métal ou d'un oxyde de métal qui a l'aptitude de réduire la quantité de la chimiokine IP-IO dans un échantillon ou de diminuer la production d'IP-IO dans les cellules. Le métal est un métal du groupe 4 ou 5 dans le tableau périodique des éléments et est de préférence le titane. Ces métaux et oxydes métalliques peuvent lier de façon sélective l'IP-IO à sa surface pour ainsi capter l'IP-IO à partir du milieu environnant. De plus, un contact métal/cellule induit une diminution de la production d'IP-IO à partir des cellules produisant l'IP-IO. Les métaux et oxydes métalliques de la présente invention peuvent être donc utilisés pour traiter et/ou prévenir des états médicaux caractérisés par l'expression défavorable d'IP-IO, tels que des réactions inflammatoires.

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