Selective cpla2 inhibitors

Details Selective cpla2 inhibitors Selective cpla2 inhibitors

C - Chemistry, Metallurgy

07

C

C07C 217/22 (2006.01) A61K 31/138 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/223 (2006.01) A61K 31/27 (2006.01) A61K 31/277 (2006.01) A61K 31/401 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/5375 (2006.01) A61K 31/661 (2006.01) A61P 1/18 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/08 (2006.01) C07C 17/269 (2006.01) C07C 25/18 (2006.01) C07C 45/51 (2006.01) C07C 45/67 (2006.01) C07C 45/74 (2006.01) C07C 49/245 (2006.01

Patent

CA 2304503

Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have general formula (i), where (R1), p, D, Y, Z, Ra, Rb and A are as defined in the specification.

Inhibiteurs sélectifs des enzymes cPLA¿2? servant à lutter contre une variété importante de maladies inflammatoires. Ces inhibiteurs sont représentés par la formule générale (i) dans laquelle (R?1¿), p, D, Y, Z, R?a¿, R?b¿ et A sont tels qu'ils sont définis dans le descriptif.

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