C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/58 (2006.01) A61K 31/675 (2006.01) A61P 19/00 (2006.01)
Patent
CA 2399976
The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1- bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms
L'invention porte sur de l'hémipentahydrate et du monohydrate de l'acide 3-pyridyl-1-hydroxyéthylidène-1,1-bisphosphonique, sel de sodium, sur des procédés de préparation desdits hémipentahydrate et monohydrate par régulation de la température de nucléation et de la vitesse de cristallisation, et sur des préparations pharmaceutiques contenant l'une des formes de ces hydrates, ou les deux.
Billings Dennis Michael
Cazer Frederick Dana
Parry Gregory Eugene
Redman-Furey Nancy Lee
Ledgley Law
The Procter & Gamble Company
Warner Chilcott Company Llc
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