Selective d1 dopamine receptor agonists and partial...

Details Selective d1 dopamine receptor agonists and partial... Selective d1 dopamine receptor agonists and partial...

C - Chemistry, Metallurgy

07

D

C07D 221/18 (2006.01) A61K 31/135 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/335 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07C 215/64 (2006.01) C07C 217/74 (2006.01) C07C 219/28 (2006.01) C07C 271/16 (2006.01) C07C 271/48 (2006.01) C07D 307/20 (2006.01) C07D 309/12 (2006.01) C07D 317/70 (2006.01) C07D 405/12 (2006.01) C07D 491/06 (2006.01) C07F 7/10 (2006.01) C07F 9/32 (2006.01) C07F 9/576 (2006.01)

Patent

CA 2247468

Disclosed are compounds (1) and (2), and derivatives and analogs thereof, which are agonists for the D1 dopamine receptor. These compounds can be used to treat an individual with Parkinson's disease. Also disclosed are monohydroxy analogs of compounds (1) and (2), and derivatives and analogs thereof, which are partial D1 agonists or antagonists. These compounds can be used to treat an individual who abuses cocaine.

L'invention a trait à des composés (1) et (2), à leurs dérivés et à leurs analogues, agonistes du récepteur de la dopamine D1. On peut utiliser ces composés pour traiter des sujets atteints de la maladie de Parkinson. Cette invention porte également sur des analogues mono-hydroxy des composés (1) et (2) ainsi que sur leurs dérivés et analogues, agonistes ou antagonistes partiels de D1. On peut utiliser ces composés pour traiter des personnes abusant de la cocaïne.

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